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Actual physical dependence on a prescribed medication will not signify dependancy. Bodily dependence consists of the prevalence of a withdrawal syndrome when there is sudden reduction or cessation in drug use or if an opiate antagonist is administered. Physical dependence may be detected after a few days of opioid therapy. Even so, clinically impor

Oral Contraceptives: Rise in glucuronidation causing enhanced plasma clearance plus a decreased 50 %-life of acetaminophen.Good evaluation on the patient, good prescribing techniques, periodic re-evaluation of therapy, and correct dispensing and storage are ideal steps that enable to Restrict abuse of opioid medications.Almost all of the instances